Finished Dosage Form bulk DESCRIPTION
Insulin aspart is a rapid-acting human insulin analog homologous with regular human insulin with the exception of a single substitution of the amino acid proline by aspartic acid in position B28, and is produced by recombinant DNA technology utilizing Saccharomyces cerevisiae (baker’s yeast). Insulin aspart has the empirical formula C256H381N65079S6 and a molecular weight of 5825.8 Da. In vitro assay confirms the minimum potency of insulin aspart to be NLT 15 units/mg.
NOVOLOG (insulin aspart) injection is a sterile, clear, and colorless solution for subcutaneous or intravenous use. Each mL contains 100 units of insulin aspart and the inactive ingredients: disodium hydrogen phosphate dihydrate (1.25 mg), glycerin (16.0 mg), metacresol (1.72 mg), phenol (1.50 mg), sodium chloride (0.58 mg),
zinc (19.6 mcg), and Water for Injection, USP. NOVOLOG has a pH of 7.2-7.6. Hydrochloric acid 10% and/or sodium hydroxide 10% may be added to adjust pH.
Mechanism of Action
The primary activity of insulin, including NOVOLOG is the regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.
Pharmacodynamics
Subcutaneous administration
The pharmacodynamic profile of NOVOLOG given subcutaneously in 22 patients with type 1 diabetes is shown
in Figure 2. The maximum glucose-lowering effect of NOVOLOG occurred between 1 and 3 hours after
subcutaneous injection (0.15 units/kg). The duration of action for NOVOLOG is 3 to 5 hours. The time course
of action of insulin and insulin analogs such as NOVOLOG may vary considerably in different individuals or
within the same individual. The parameters of NOVOLOG activity (time of onset, peak time and duration) as
designated in Figure 2 should be considered only as general guidelines. The rate of insulin absorption and onset
of activity is affected by the site of injection, exercise, and other variables.
Name: Insulin Aspart
Insulin Aspart is a man made insulin that is used to control high blood sugar in adults and children with diabetes mellitus.
Dosage: Injection
Specification
3ml: 300units
Indications
Insulin Aspart is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus.
Hangzhou Jiuyuan is a top-biotech joint venture specializing in the research, development, manufacture, and marketing of pharmaceuticals based on gene engineering and biochemical technology since 1993. It has gene engineering workshops, injection workshops, pharmaceutical API workshops, and other sections including the quality management department, warehouse, engineering department, etc., all of which are built according to GMP requirements. Jiuyuan is equipped with advanced production and analysis instruments like chromatography systems, HPLC, and capillary electrophoresis.
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Company Honor
National New High-tech Enterprise
Key New High-tech Enterprise of National Torch Plan
National superior enterprise of intellectual property
Provincial New High-tech Research & Development Center
Zhejiang Provincial Enterprise Technology Center
Zhejiang Famous Trademark
Zhejiang Jiuyuan Gene Engineering Biopharmaceutical Research Institute
FAQ
Q: How long is your delivery time?
A: The general delivery time is 30-45 days after receiving your order confirmation. if we have the goods in stock, it will only take 1-2 days.
Q: Do you provide sample? Is it free?
A: If the sample is low value, we will provide the free sample with freight collect. But for some high value samples, we need to collect the sample charge.
Q: What is your term of payment?
A: 30% down payment before producing and 70% balance payment before shipping.
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A: T/T, Western Union, PayPal etc. We accept any convenient and swift payment term.
Q: Which certificate do you have?
A: GMP, EUGMP and ISO14001.Finished Dosage Form bulk